Red-hot 49ers beat Philip Rivers-led Colts: Winners, losers from MNF
- - Red-hot 49ers beat Philip Rivers-led Colts: Winners, losers from MNF
Tyler Dragon, USA TODAYDecember 23, 2025 at 5:59 AM
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Red-hot 49ers beat Philip Rivers-led Colts: Winners, losers from MNF
The playoff-bound San Francisco 49ers are getting hot at the right time.
The 49ers got by the Indianapolis Colts, 48-27, to win their fifth consecutive game.
Conversely, the Colts have now lost five straight games.
Brock Purdy and the 49ers scored on their first four drives of the game, and carried their momentum into the second half against a defenseless Colts team.
Purdy tossed a career-best five touchdown passes. Philip Rivers played admirably, but it wasn’t enough to defeat the red-hot 49ers.
Here are the winners and losers from the interconference matchup on "Monday Night Football":
their new "Rivalries" uniform for the "Sunday Night Football" game, which the Patriots won, 23-20.
" style=padding-bottom:56%>Week 5: Buffalo Bills wide receiver Curtis Samuel makes a catch against the New England Patriots at Highmark Stadium. The Bills wore their new "Rivalries" uniform for the "Sunday Night Football" game, which the Patriots won, 23-20.
" data-src=https://s.yimg.com/ny/api/res/1.2/ZeGhPQgsXq6Ng1blD2CNGQ--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/7c3f337bbc44f0dd99f902e2d29228c9 class=caas-img data-headline="Can't-miss alternate and throwback uniforms of the 2025 NFL season" data-caption="
Week 5: Buffalo Bills wide receiver Curtis Samuel makes a catch against the New England Patriots at Highmark Stadium. The Bills wore their new "Rivalries" uniform for the "Sunday Night Football" game, which the Patriots won, 23-20.
">Week 5: Buffalo Bills wide receiver Curtis Samuel makes a catch against the New England Patriots at Highmark Stadium. The Bills wore their new "Rivalries" uniform for the "Sunday Night Football" game, which the Patriots won, 23-20.
" src=https://s.yimg.com/ny/api/res/1.2/ZeGhPQgsXq6Ng1blD2CNGQ--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/7c3f337bbc44f0dd99f902e2d29228c9 class=caas-img>
Week 5: Tampa Bay Buccaneers quarterback Baker Mayfield awaits the snap against the Seattle Seahawks at Lumen Field. Both teams wore throwback uniforms in the Buccaneers' 38-35 win. The Buccaneers and Seahawks entered the NFL together as expansion teams in 1976.
" data-src=https://s.yimg.com/ny/api/res/1.2/TT2oM2YXMJa1o5DH2w6Ufg--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/677f39c594a84d31620582c122cca70a class=caas-img data-headline="Can't-miss alternate and throwback uniforms of the 2025 NFL season" data-caption="
Week 5: Tampa Bay Buccaneers quarterback Baker Mayfield awaits the snap against the Seattle Seahawks at Lumen Field. Both teams wore throwback uniforms in the Buccaneers' 38-35 win. The Buccaneers and Seahawks entered the NFL together as expansion teams in 1976.
">Week 5: Tampa Bay Buccaneers quarterback Baker Mayfield awaits the snap against the Seattle Seahawks at Lumen Field. Both teams wore throwback uniforms in the Buccaneers' 38-35 win. The Buccaneers and Seahawks entered the NFL together as expansion teams in 1976.
" src=https://s.yimg.com/ny/api/res/1.2/TT2oM2YXMJa1o5DH2w6Ufg--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/677f39c594a84d31620582c122cca70a class=caas-img>
"Monday Night Football" game against the Cincinnati Bengals at Empower Field at Mile High. The Broncos wore their "Midnight Navy" uniforms for the 28-3 win.
" style=padding-bottom:56%>Week 4: Denver Broncos quarterback Bo Nix (10) hands the ball off to running back J.K. Dobbins during the "Monday Night Football" game against the Cincinnati Bengals at Empower Field at Mile High. The Broncos wore their "Midnight Navy" uniforms for the 28-3 win.
" data-src=https://s.yimg.com/ny/api/res/1.2/aS2oirAk5mt9j6wPx42IJw--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/3a30b18fa97e5116121c6b97691eb4d3 class=caas-img data-headline="Can't-miss alternate and throwback uniforms of the 2025 NFL season" data-caption="
Week 4: Denver Broncos quarterback Bo Nix (10) hands the ball off to running back J.K. Dobbins during the "Monday Night Football" game against the Cincinnati Bengals at Empower Field at Mile High. The Broncos wore their "Midnight Navy" uniforms for the 28-3 win.
">Week 4: Denver Broncos quarterback Bo Nix (10) hands the ball off to running back J.K. Dobbins during the "Monday Night Football" game against the Cincinnati Bengals at Empower Field at Mile High. The Broncos wore their "Midnight Navy" uniforms for the 28-3 win.
" src=https://s.yimg.com/ny/api/res/1.2/aS2oirAk5mt9j6wPx42IJw--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/3a30b18fa97e5116121c6b97691eb4d3 class=caas-img>a 27-21 win on "Monday Night Football" at Hard Rock Stadium. The Dolphins wore their new their Nike "Rivalries" uniforms – the team version dubbed "Dark Waters."
" style=padding-bottom:56%>Week 4: Miami Dolphins running back De'von Achane rushes the ball against the New York Jets during a 27-21 win on "Monday Night Football" at Hard Rock Stadium. The Dolphins wore their new their Nike "Rivalries" uniforms – the team version dubbed "Dark Waters."
" data-src=https://s.yimg.com/ny/api/res/1.2/GeSzEbaRz.fpqDCpehKfuw--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/ea9c55e0ff8d3c0cef4124211fe79ed8 class=caas-img data-headline="Can't-miss alternate and throwback uniforms of the 2025 NFL season" data-caption="
Week 4: Miami Dolphins running back De'von Achane rushes the ball against the New York Jets during a 27-21 win on "Monday Night Football" at Hard Rock Stadium. The Dolphins wore their new their Nike "Rivalries" uniforms – the team version dubbed "Dark Waters."
">Week 4: Miami Dolphins running back De'von Achane rushes the ball against the New York Jets during a 27-21 win on "Monday Night Football" at Hard Rock Stadium. The Dolphins wore their new their Nike "Rivalries" uniforms – the team version dubbed "Dark Waters."
" src=https://s.yimg.com/ny/api/res/1.2/GeSzEbaRz.fpqDCpehKfuw--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/ea9c55e0ff8d3c0cef4124211fe79ed8 class=caas-img>the first NFL team to wear the new Nike "Rivalries" uniform in a game. The Seahawks won the game, 23-20.
" style=padding-bottom:56%>Week 4: The Arizona Cardinals defense tackles Seattle Seahawks wide receiver Tory Horton (15) during the first quarter of a "Thursday Night Football" game at State Farm Stadium. The Cardinals became the first NFL team to wear the new Nike "Rivalries" uniform in a game. The Seahawks won the game, 23-20.
" data-src=https://s.yimg.com/ny/api/res/1.2/BgOsyh6FU1hUZ9JUWzDPtA--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/d7d4c1e0279b1ffac6eb7e0dddfae709 class=caas-img data-headline="Can't-miss alternate and throwback uniforms of the 2025 NFL season" data-caption="
Week 4: The Arizona Cardinals defense tackles Seattle Seahawks wide receiver Tory Horton (15) during the first quarter of a "Thursday Night Football" game at State Farm Stadium. The Cardinals became the first NFL team to wear the new Nike "Rivalries" uniform in a game. The Seahawks won the game, 23-20.
">Week 4: The Arizona Cardinals defense tackles Seattle Seahawks wide receiver Tory Horton (15) during the first quarter of a "Thursday Night Football" game at State Farm Stadium. The Cardinals became the first NFL team to wear the new Nike "Rivalries" uniform in a game. The Seahawks won the game, 23-20.
" src=https://s.yimg.com/ny/api/res/1.2/BgOsyh6FU1hUZ9JUWzDPtA--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/d7d4c1e0279b1ffac6eb7e0dddfae709 class=caas-img>
Week 3: New Orleans Saints running back Kendre Miller (5) stiff arms Seattle Seahawks linebacker Tyrice Knight (48) during the second quarter at Lumen Field. The Saints wore their all-white uniform and helmet combo for the first time in the 44-13 loss.
" data-src=https://s.yimg.com/ny/api/res/1.2/56la2TSls8UGPl1fnusZ_g--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/f8b85f04ffcb38123704a83197911f65 class=caas-img data-headline="Can't-miss alternate and throwback uniforms of the 2025 NFL season" data-caption="
Week 3: New Orleans Saints running back Kendre Miller (5) stiff arms Seattle Seahawks linebacker Tyrice Knight (48) during the second quarter at Lumen Field. The Saints wore their all-white uniform and helmet combo for the first time in the 44-13 loss.
">Week 3: New Orleans Saints running back Kendre Miller (5) stiff arms Seattle Seahawks linebacker Tyrice Knight (48) during the second quarter at Lumen Field. The Saints wore their all-white uniform and helmet combo for the first time in the 44-13 loss.
" src=https://s.yimg.com/ny/api/res/1.2/56la2TSls8UGPl1fnusZ_g--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/f8b85f04ffcb38123704a83197911f65 class=caas-img>Week 3: San Francisco 49ers running back Christian McCaffrey carries the ball against the Arizona Cardinals during the first half at Levi's Stadium. The 49ers wore throwback jerseys - an homage to the team's 1950s look, as well as its 1994 Super Bowl-winning season - in the 16-15 win against the Cardinals.
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Week 3: San Francisco 49ers running back Christian McCaffrey carries the ball against the Arizona Cardinals during the first half at Levi's Stadium. The 49ers wore throwback jerseys - an homage to the team's 1950s look, as well as its 1994 Super Bowl-winning season - in the 16-15 win against the Cardinals.
">Week 3: San Francisco 49ers running back Christian McCaffrey carries the ball against the Arizona Cardinals during the first half at Levi's Stadium. The 49ers wore throwback jerseys - an homage to the team's 1950s look, as well as its 1994 Super Bowl-winning season - in the 16-15 win against the Cardinals.
" src=https://s.yimg.com/ny/api/res/1.2/bpStb24k6.UoY2gUP0YIEA--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD0xODYz/https://media.zenfs.com/en/usa_today_slideshows_242/ad3fed8890f4fb81879fd0e858d43b85 class=caas-img>
Week 2: Minnesota Vikings quarterback J.J. McCarthy (9) runs the ball against the Atlanta Falcons at U.S. Bank Stadium. Sporting "The Vikings Classic" throwback uniform inspired by the team's look during the 1960s and '70s, Minnesota was defeated, 22-6.
" data-src=https://s.yimg.com/ny/api/res/1.2/iVS54rP.I_InQtCpOctWCA--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/39b932830e47d58b5bf101ed5364299e class=caas-img data-headline="Can't-miss alternate and throwback uniforms of the 2025 NFL season" data-caption="
Week 2: Minnesota Vikings quarterback J.J. McCarthy (9) runs the ball against the Atlanta Falcons at U.S. Bank Stadium. Sporting "The Vikings Classic" throwback uniform inspired by the team's look during the 1960s and '70s, Minnesota was defeated, 22-6.
">Week 2: Minnesota Vikings quarterback J.J. McCarthy (9) runs the ball against the Atlanta Falcons at U.S. Bank Stadium. Sporting "The Vikings Classic" throwback uniform inspired by the team's look during the 1960s and '70s, Minnesota was defeated, 22-6.
" src=https://s.yimg.com/ny/api/res/1.2/iVS54rP.I_InQtCpOctWCA--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/39b932830e47d58b5bf101ed5364299e class=caas-img>
1 / 25Can't-miss alternate and throwback uniforms of the 2025 NFL seasonWeek 6: Washington Commanders wide receiver Chris Moore (19) celebrates with teammates after scoring a touchdown during the "Monday Night Football" game against the Chicago Bears at Northwest Stadium. The Commanders wore their all-black alternate uniforms for the game.WINNERSCareer night for Brock Purdy
The 49ers QB is playing well.
Purdy threw for 295 yards and a career-high five touchdown passes in the win.
Purdy completed 25 of his 35 passes. He had one inaccurate ball that he threw a little high to WR Kendrick Bourne that was picked off by Colts safety Cam Bynum.
Overall, Purdy was efficient all game. He had 151 passing yards, and three touchdown passes in the first half alone.
Career high five touchdowns for Brock Purdy 🔥SFvsIND on ESPNStream on @NFLPlus and ESPN App pic.twitter.com/xhMae1Jawk
— NFL (@NFL) December 23, 2025
Purdy and the 49ers offense haven't punted in the month of December.
Christian McCaffrey, George Kittle
The 49ers offense continues to revolve around their two star playmakers.
McCaffrey is the engine to the 49ers offense. The running back had 27 touches, 146 yards from scrimmage and two touchdowns.
Kittle tallied seven catches for 115 yards and a touchdown.
Kittle injured his ankle in the second half. The 49ers initially ruled him questionable to return but he never made it back into the game.
San Francisco has a chance to clinch the No. 1 seed in the NFC if it wins its next two games, but the 49ers can’t afford to lose Kittle or McCaffrey.
Dee Winters takes one to house
Winters got his first career interception when he stepped in from of a pass intended for tight end Tyler Warren. The 49ers linebacker caught the football and returned it 74 yards to the house.
PICKED BY DEE WINTERS AND GOING 75 YARDS TO THE HOUSESFvsIND on ESPNStream on @NFLPlus and ESPN App pic.twitter.com/PChK24B767
— NFL (@NFL) December 23, 2025
The pick-six sealed the win for San Francisco.
Christmas gift for Kendrick Bourne
Bourne earned his $500,000 receiving yards bonus on Monday night. A nice holiday bonus for the wideout who’s had a nice year in San Francisco.
Philip Rivers impressive in second start
Anything Rivers does at this point is a win. It’s hard to call the 44-year-old Rivers a loser playing in his second game after a five-year hiatus.
With his family watching in a suite, Rivers carved the 49ers up during Indy’s opening series. Rivers completed 5-of-7 passes for 73 yards on the Colts’ nine-play, 72-yard touchdown drive.
Rivers completed 23-of-35 passes for 277 yards to go with two touchdowns and one interception. It was the first time Rivers passed for over 275 yards since Dec. 6, 2020.
Rivers still has good accuracy and anticipation. His familiarity with Shane Steichen’s offense is evident.
nothing but respect between Philip Rivers & Brock Purdy pic.twitter.com/ortXnMljWD
— NFL (@NFL) December 23, 2025
Buffalo Bills, Jacksonville Jaguars, Los Angeles Chargers
The Bills, Jaguars and Chargers each clinched a playoff berth because of San Francisco’s win over Indianapolis on Monday. The three playoff-bound AFC teams owe the 49ers a Christmas present.
California NFL teams
All three NFL teams in the Golden State have clinched a playoff spot.
makes a catch for a touchdown against the Green Bay Packers during the fourth quarter at Lambeau Field. The play was originally ruled an incomplete pass, but the call was overturned. Despite TeSlaa's effort, the Packers won the game 27-13.
" style=padding-bottom:56%>Week 1: Detroit Lions wide receiver Isaac TeSlaa (18) makes a catch for a touchdown against the Green Bay Packers during the fourth quarter at Lambeau Field. The play was originally ruled an incomplete pass, but the call was overturned. Despite TeSlaa's effort, the Packers won the game 27-13.
" data-src=https://s.yimg.com/ny/api/res/1.2/fo8okmfdHRvDHl_AjAyGtw--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/ece3b009de0e7aba961c9dfc2585f6aa class=caas-img data-headline="Best images of the 2025 NFL season" data-caption="
Week 1: Detroit Lions wide receiver Isaac TeSlaa (18) makes a catch for a touchdown against the Green Bay Packers during the fourth quarter at Lambeau Field. The play was originally ruled an incomplete pass, but the call was overturned. Despite TeSlaa's effort, the Packers won the game 27-13.
">Week 1: Detroit Lions wide receiver Isaac TeSlaa (18) makes a catch for a touchdown against the Green Bay Packers during the fourth quarter at Lambeau Field. The play was originally ruled an incomplete pass, but the call was overturned. Despite TeSlaa's effort, the Packers won the game 27-13.
" src=https://s.yimg.com/ny/api/res/1.2/fo8okmfdHRvDHl_AjAyGtw--/YXBwaWQ9aGlnaGxhbmRlcjt3PTEyNDI7aD04Mjg-/https://media.zenfs.com/en/usa_today_slideshows_242/ece3b009de0e7aba961c9dfc2585f6aa class=caas-img>
1 / 4Best images of the 2025 NFL season
Week 1: Detroit Lions wide receiver Isaac TeSlaa (18) makes a catch for a touchdown against the Green Bay Packers during the fourth quarter at Lambeau Field. The play was originally ruled an incomplete pass, but the call was overturned. Despite TeSlaa's effort, the Packers won the game 27-13.
LOSERSDefense
There was little resistance from either defense, especially in the first half.
Both offenses combined for 41 points, 444 yards and 27 first downs in the first half. The 49ers averaged 7.6 yards per play. Indianapolis averaged 6.5 yards per play.
The defensive units played a little better in the second half.
Niners defensive tackle Alfred Collins had a strip sack in the fourth quarter that ruined a Colts drive.
Colts safety Cam Bynum had an interception. San Francisco linebacker Dee Winters had a pick-six.
Sauce Gardner-less Colts defense
The Colts certainly miss Gardner.
The 49ers scored on their first four series, including three touchdown drives.
San Francisco scored on seven total drives and gained 440 yards on a helpless Colts defense. The 49ers averaged 6.7 yards per play and didn’t punt once.
Ameer Abdullah
Abdullah fumbled on his first kickoff return and gave San Francisco ideal field position at Indy’s 26-yard line. The 49ers capitalized off the turnover with a touchdown five plays later to take a 14-7 first-quarter lead.
Follow USA TODAY Sports' Tyler Dragon on X @TheTylerDragon.
This article originally appeared on USA TODAY: MNF winners and losers: Brock Purdy has career night in 49ers win
Source: “AOL Sports”
